The scientific theorist is not to be envied. For Nature, or more precisely experiment, is an exorable and not very friendly judge of his work. It never says "yes" to a theory. In the most favorable cases it says "Maybe," and in the great majority of cases simply "No." If an experiment agrees with a theory it means for the latter "Maybe," and if it does not agree it means "No." Probably every theory will some day experience its "No" - most theories, soon after conception.
Albert EinsteinAs soon as science has emerged from its initial stages, theoretical advances are no longer achieved merely by a process of arrangement. Guided by empirical data, the investigator rather develops a system of thought which, in general, is built up logically from a small number of fundamental assumptions, the so-called axioms. We call such a system of thought a theory. The theory finds the justification for its existence in the fact that it correlates a large number of single observations, and it is just here that the 'truth' of the theory lies.
Albert Einstein