[V]igor of government is essential to the security of liberty.

The scheme of separate confederacies, which will always multiply the chances of ambition, will be a never failing bait to all such influential characters in the State administrations as are capable of preferring their own emolument and advancement to the public weal.

The regular distribution of power into distinct departments; the introduction of legislative balances and checks; the institution of courts composed of judges holding their offices during good behavior; the representation of the people in the legislature by deputies of their own election . . . They are means, and powerful means, by which the excellences of republican government may be retained and its imperfections lessened or avoided.

What bitter anguish would not the people of Athens have often escaped if their government had contained so provident a safeguard against tyranny of their own passions? Popular liberty might then have escaped the indelible reproach of decreeing to the same citizens the hemlock on one day and statutes the next.

It is a general principle of human nature, that a man will be interested in whatever he possesses, in proportion to the firmness or precariousness of the tenure by which he holds it; will be less attached to what he holds by a momentary or uncertain title, than to what he enjoys by a durable or certain title; and, of course, will be willing to risk more for the sake of the one, than for the sake of the other.

It has been observed, [that for the federal government] to coerce the States is one of the maddest projects that was ever devised.

To model our political system upon speculations of lasting tranquility, is to calculate on the weaker springs of the human character.