A friend and I flew south with our children. During the week we spent together I took off my shoes, let down my hair, took apart my psyche, cleaned the pieces, and put them together again in much improved condition. I feel like a car that's just had a tune-up. Only another woman could have acted as the mechanic.

Your kids are launched. You love your work but you understand how to place it in the panorama of the rest of your life. There's this line in the book, and when I wrote it I thought yes, that's it - if you think of life as a job, maybe by the time you get to, say, in my case, 60, you've finally gotten good at it.

I don't really read what people write about me. Someone gives my novel one star; are they a troll? Are they someone who hates my politics and so has decided to do that?

You realize that these accidental decisions you make about changing jobs, about moving into an apartment where you make new friends and confidants, about going to one city over another, that sometimes they're completely arbitrary decisions that you haven't put as much thought into as perhaps you should have, and yet they change the course of your whole life.

There may perhaps be a new generation of doctors horrified by lacerations, infections, women who have douched with kitchen cleanser. What an irony it would be if fanatics continued to kill and yet it was the apathy and silence of the medical profession that most wounded the ability to provide what is, after all, a medical procedure.

The unemployment rate among the young in the United States is still very disconcerting, although we all know it's nowhere near as bad as it is in some of the European countries, where in some places it approaches 50 percent.

When you look at the women that have made a real difference in the world throughout history, what they’ve done has almost always been defined by fearlessness. That’s something I came to at a certain point; I wish I’d come to it younger. Stop looking over your shoulder — there’s nobody who matters back there.