There is always the temptation in life to diddle around making itsy-bitsy friends and meals and journeys for years on end. It is all so self conscience, so apparently moral...But I won't have it. The world is wilder than that in all directions, more dangerous...more extravagant and bright. We are...raising tomatoes when we should be raising Cain, or Lazarus.

If I actually believed that the progress of human understanding depended on our crop of contemporary novelists, I would shoot myself.

To crank myself up I stood on a jack and ran myself up. I tightened myself like a bolt. I inserted myself in a vise-clamp and wound the handle till the pressure built. I drank coffee in titrated doses. It was a tricky business, requiring the finely tuned judgment of a skilled anesthesiologist. There was a tiny range within which coffee was effective, short of which it was useless, and beyond which, fatal.

You have to take pains in a memoir not to hang on the reader's arm, like a drunk, and say, 'And then I did this and it was so interesting.

For all the insularity of the old guard, Pittsburgh was always an open and democratic town.

Admire the world for never ending on you -- as you would an opponent, without taking your eyes away from him, or walking away.

All the green in the planted world consists of these whole, rounded chloroplasts wending their ways in water. If you analyze a molecule of chlorophyll itself, what you get is one hundred thirty-six atoms of hydrogen, carbon, oxygen, and nitrogen arranged in an exact and complex relationship around a central ring. At the ring's center is a single atom of magnesium. Now: If you remove the atom of magnesium and in its exact place put an atom of iron, you get a molecule of hemoglobin. The iron atom combines with all the other atoms to make red blood, the streaming red dots in the goldfish's tail.