The written word is weak. Many people prefer life to it. Life gets your blood going, & it smells good. Writing is mere writing, literature is mere. It appeals only to the subtlest senses—the imagination’s vision, & the imagination’s hearing—& the moral sense, & the intellect. This writing that you do, that so thrills you, that so rocks & exhilarates you, as if you were dancing next to the band, is barely audible to anyone else.

I cannot imagine a sorrier pursuit than struggling for years to write a book that attempts to appeal to people who do not read in the first place.

Geography is the key, the crucial accident of birth. A piece of protein could be a snail, a sea lion, or a systems analyst, but it had to start somewhere. This is not science; it is merely metaphor. And the landscape in which the protein "starts" shapes its end as surely as bowls shape water.

There is neither a proportional relationship, nor an inverse one, between a writer’s estimation of a work in progress & its actual quality. The feeling that the work is magnificent, & the feeling that it is abominable, are both mosquitoes to be repelled, ignored, or killed, but not indulged.

Young children have no sense of wonder. They bewilder well, but few things surprise them. All of it is new to young children, after all, and equally gratuitous.

For all the insularity of the old guard, Pittsburgh was always an open and democratic town.

Let the grass die. I let almost all of my indoor plants die from neglect while I was writing the book. There are all kinds of ways to live. You can take your choice. You can keep a tidy house, and when St. Peter asks you what you did with your life, you can say, I kept a tidy house, I made my own cheese balls.