People relate to things that feel real to them. All the good, happy, over-sexed and moneyed endings on TV are not the way most of us feel in our lives. The success of 'E.R.,' I think, is not relying on overly sentimental stories that are solved where people's lives wrap up nicely with happy endings.

I love being a part of something that is grassroots, and you can see the actual changes, the effect of what people do.

To be a good actor you really have to want to act first.

I did tons of theater in school, and then when I was 16 and got my driver's license, I started driving to Los Angeles, along with my friend Eric Stoltz, who was a year ahead of me and was doing the same thing. So we had the same manager, and we started auditioning for things and doing commercials when we were 16.

I just spent a lot of time on 'ER' for that eight years. I also started working when I was 16, so by the time I left 'ER,' I was 40 years old, I had this incredible experience, my wife had this great company, we had four kids, it was like, 'Let's go to New York and live for a while and make that the priority.'

'ER' was so huge that whatever I did coming back to television, I'd have to feel as strongly about.

David Fincher is a longtime friend. As a director, my wife had worked with him as a makeup artist when he would do Madonna videos years before, and his child and my oldest child were in preschool together, so we're kind of dad-friends through that, too.