The nature of a protective immune response to HIV is still unclear. Because in a very, very unique manner, unlike virtually any other microbe with which we're familiar, the HIV virus has evolved in a way that the immune system finds it very difficult, if not impossible, to deal with the virus.
Anthony S. FauciYou can have an epidemic in a state. You can have it in a region. You can have it in a country where the critical level of disease passes a certain threshold and we call that an epidemic threshold.
Anthony S. Fauci