There is nothing more stimulating than a case where everything goes against you.

The stage lost a fine actor, even as science lost an acute reasoner, when [Holmes] became a specialist in crime.

When a doctor does go wrong he is the first of criminals. He has nerve and he has knowledge.

The world is full of obvious things which nobody by any chance ever observes.

The Adventure of the Noble Bachelor

It has always seemed to me that so long as you produce your dramatic effect, accuracy of detail matters little. I have never striven for it and I have made some bad mistakes in consequence. What matter if I hold my readers?

I do hate the City of London! It is the only thing which ever comes between us.