What is the meaning of it, Watson? said Holmes solemnly as he laid down the paper. "What object is served by this circle of misery and violence and fear? It must tend to some end, or else our universe is ruled by chance, which is unthinkable. But what end? There is the great standing perennial problem to which human reason is as far from an answer as ever.

The weak man becomes strong when he has nothing, for then only can he feel the wild, mad thrill of despair.

"There are one or two elementary rules to be observed in the way of handling patients," he remarked, seating himself on the table and swinging his legs. "The most obvious is that you must never let them see that you want them. It should be pure condescension on your part seeing them at all; and the more difficulties you throw in the way of it, the more they think of it. Break your patients in early, and keep them well to heel."

It is quite a three pipe problem, and I beg that you won't speak to me for fifty minutes.

You cannot see the lettuce and the dressing without suspecting a salad.

And yet the motives of women are so inscrutable. You remember the woman at Margate whom I suspected for the same reason. No powder on her nose - that proved to be the correct solution. How can you build on such a quicksand? Their most trivial action may mean volumes, or their most extraordinary conduct may depend upon a hairpin or a curling tongs.

It is with nations as it is with individuals. A book of history is a book of sermons.