It has long been an axiom of mine that the little things are infinitely the most important.

His incredible untidiness, his addiction to music at strange hours, his occasional revolver practice within doors, his weird and often malodorous scientific experiments, and the atmosphere of violence and danger which hung around him made him the very worst tenant in London.

It is hardly fair to blame America for the state of San Francisco, for its population is cosmopolitan and its seaport attracts the floating vice of the Pacific; but be the cause what it may, there is much room for spiritual betterment.

‎A change of work is the best rest.

My sister and I, you will recollect, were twins, and you know how subtle are the links which bind two souls which are so closely allied.

To a great mind, nothing is little,' remarked Holmes, sententiously.

We balance probabilities and choose the most likely. It is the scientific use of the imagination.