In modern pharmacology it's so clear that even if you have a fixed dose of a drug, the individuals respond very differently to one and the same dose.
Arvid CarlssonFluorine has a protecting action against caries, but this is a local effect. If you drink it, you are running the risk of all kinds of toxic actions.
Arvid CarlssonWell, in pharmacology, if the effect is local, it's of course absolutely awkward to use it in any other way than as a local treatment.
Arvid CarlssonIn Sweden, water fluoridation, to my knowledge, is no longer advocated by anybody. In Sweden, the emphasis nowadays is to keep the environment as clean as possible with regard to pharmacologically active and, thus, potentially toxic substances.
Arvid CarlssonIt is my sincere hope that Christopher Bryson's apparently thorough and comprehensive perusal of the scientific literature on the biological actions of fluoride and the ensuing debates through the years will receive the attention it deserves and that its implications will be seriously considered.
Arvid Carlsson