Some things tend not to work so well for science - things that rely on substantial written contributions by key experts are a case in point - but even there I tend to keep an open mind, because it may just be a case of finding the right formula.

The aim is to postpone frailty, postpone degenerative disease, debilitation and so on and thereby shorten the period at the end of life, which is passed in a decrepit or disabled state, while extending life as a whole.

Basically, the body does have a vast amount of inbuilt anti-ageing machinery; it's just not 100% comprehensive, so it allows a small number of different types of molecular and cellular damage to happen and accumulate.

Theres no such thing as ageing gracefully. I dont meet people who want to get Alzheimers disease, or who want to get cancer or arthritis or any of the other things that afflict the elderly. Ageing is bad for you, and we better just actually accept that.

Accept the difficulty of what you cannot yet change. But do not accept the impossibility of ever changing it.

Theres nothing wrong with making the best of ones declining years, but what does annoy me is the fatalism. Now that were seriously in range of finding therapies that actually work against ageing, this apathy, of course, becomes an enormous part of the problem.

I think it's reasonable to suppose that one could oscillate between being biologically 20 and biologically 25 indefinitely.