National boundaries these days are not that important because of transformative technological development. Now we are talking about the fourth industrial revolution.

It is only natural that people's wishes and aspirations should be realized by the leaders of the region. As this wind of change blows, it is up to the leaders to seize this opportunity to look for the better future for their own people through bold reforms before it is too late, before the people are forced to take action.

One of the main lessons I have learned during my five years as Secretary-General is that broad partnerships are the key to solving broad challenges. When governments, the United Nations, businesses, philanthropies and civil society work hand-in-hand, we can achieve great things.

The taking of life is too absolute, too irreversible, for one human being to inflict on another, even when backed by legal process. Where the death penalty persists, conditions for those awaiting execution are often horrifying, leading to aggravated suffering.

Nuclear terrorism is one of the most serious threats of our time. Even one such attack could inflict mass casualties and create immense suffering and unwanted change in the world forever. This prospect should compel all of us to act to prevent such a catastrophe.

Violence against women continues to persist as one of the most heinous, systematic and prevalent human rights abuses in the world. It is a threat to all women, and an obstacle to all our efforts for development, peace, and gender equality in all societies. Violence against women is always a violation of human rights; it is always a crime; and it is always unacceptable. Let us take this issue with the deadly seriousness that it deserves.

We have seen in the past where leaders have not been open-minded or have not been flexible. That's why the people came out to the streets and shouted and chanted for more reforms and more freedoms.