If we want to make the best products, we also have to invest in the best ideas... Every dollar we invested to map the human genome returned $140 to our economy... Today, our scientists are mapping the human brain to unlock the answers to Alzheimer's... Now is not the time to gut these job-creating investments in science and innovation. Now is the time to reach a level of research and development not seen since the height of the Space Race.

Globalization combined with technology, combined with social media and constant information, have disrupted people's lives sometimes in very concrete ways; a manufacturing plant closes and suddenly an entire town no longer has what was the primary source of employment.

Nobody wants to put the creditworthiness of the United States in jeopardy. Nobody wants to see the United States default. So we've got to seize this moment, and we have to seize it soon.

To young people: you have to stay encouraged.

Health care got done because there were a lot of people out there who aren't professional politicians, but are citizens, who pushed for it even when the politics was hard.

I think we want to see new voices and new ideas emerge - that's part of the reason why term limits are a really useful thing.

I'm especially grateful that they're here at a time when the rest of Ireland is focused on the final round of the Six Nations rugby tournament and the last match of the legendary Brian O'Driscoll.