From the point of view of the pharmaceutical industry, the AIDS problem has already been solved. After all, we already have a drug which can be sold at the incredible price of $8,000 an annual dose, and which has the added virtue of not diminishing the market by actually curing anyone.

I think it's tragic that we have this human capacity, which appears to be hardwired, or so the evolutionary biologists say, for collective joy. We have these techniques for generating it that go back thousands of years, and yet we tend not to use this.

One of the most essential and mundane of human activities - taking care of children - requires high levels of anxious vigilance. ... [Parents] dare not risk assuming that the sudden quiet from the toddlers' room means they are studying with Baby Einstein. Visualize fratricidal stranglings and electric outlets stabbed with forks: this is how we have reproduced our genomes.

I grew up hearing over and over, to the point of tedium, that "hard work" was the secret of success: "Work hard and you'll get ahead" or "It's hard work that got us where we are." No one ever said that you could work hard - harder even than you ever thought possible - and still find yourself sinking ever deeper into poverty and debt.

For anyone worn down, The Impossible Will Take a Little While is a bracing double cappuccino.

There's more pressure on women to be chirpy and perky.

Upscale people are fixated with food simply because they are now able to eat so much of it without getting fat, and the reason they don't get fat is that they maintain a profligate level of calorie expenditure. The very same people whose evenings begin with melted goats cheese... get up at dawn to run, break for a mid-morning aerobics class, and watch the evening news while racing on a stationary bicycle.