The incessant driving of the pen over paper causes intense fatigue of the hand and the whole arm because of the continuous ... strain on the muscles and tendons.

Those who work standing ... carpenters, sawyers, carvers, blacksmiths, masons ... are liable to varicose veins ... [because] the strain on the muscles is such that the circulation of the blood is retarded. Standing even for a short time proves exhausting compared with walking and running though it be for a long time ... Nature delights and is restored by alternating and varied actions.

...those who sit at their work and are therefore called 'chair workers,' such as cobblers and tailors, suffer from their own particular diseases ... [T]hese workers ... suffer from general ill-health and an excessive accumulation of unwholesome humors caused by their sedentary life ... so to some extent counteract the harm done by many days of sedentary life. On the association between chronic inactivity and poor health. Ramazzini urged that workers should at least exercise on holidays

[I have seen] workers in whom certain morbid affections gradually arise from some particular posture of the limbs or unnatural movements of the body called for while they work. Such are the workers who all day stand or sit, stoop or are bent double, who run or ride or exercise their bodies in all sorts of [excess] ways. ... the harvest of diseases reaped by certain workers ... [from] irregular motions in unnatural postures of the body.

I have noticed bakers with swelled hands, and painful, too; in fact the hands of all such workers become much thickened by the constant pressure of kneading the dough.

The mortality of those who dig minerals is very great, and women who marry men of this sort marry again and again. According to Agricola, at the mines in the Carpathian mountains, women have been known to marry seven times.

An acquaintance of mine, a notary by profession, who, by perpetual writing, began first to complain of an excessive wariness of his whole right arm which could be removed by no medicines, and which was at last succeeded by a perfect palsy of the whole arm. . . . He learned to write with his left hand, which was soon thereafter seized with the same disorder.