AIDS we're - most of these diseases - we are down from the peak. We're down about 40 per cent from the peak and if we got the right vaccines, which are at the early stage of discovering, then the numbers would come down very dramatically. So that's why we talk about it as an emergency.

There are a variety of techniques for breaking software down into pieces and making software development more efficient. Many of these techniques have been sort of... and everybody got excited about but very little benefit was actually derived once the thing was put into practice.

I have always loved the competitive forces in this business. You know I certainly have meetings where I spur people on by saying, "Hey, we can do better than this. How come we are not out ahead on that?" Thats what keeps my job one of the most interesting in the world.

The world is progressing and resources are becoming more abundant. I'd rather go into a grocery store today than a king's banquet a hundred years ago.

Software is a great combination between artistry and engineering. When you finally get done and get to appreciate what you have done it is like a part of yourself that you've put together. I think a lot of the people here feel that way.

As I see it, there are two great forces of human nature: self-interest, and caring for others. Capitalism harnesses self-interest in a helpful and sustainable way, but only on behalf of those who can pay. Government aid and philanthropy channel our caring for those who can't pay. But to provide rapid improvement for the poor we need a system that draws in innovators and businesses in a far better way than we do today.

I'm an investor in a number of biotech companies, partly because of my incredible enthusiasm for the great innovations they will bring.