The quality of research in the U.S. is absolutely the best.

here are economies like China's economy where it's less than a tenth [of a percent] today, although it is growing, is quite small, because of the notion that the government takes care of everything, and Europe and China, philanthropy has not been nearly of the same scale.

The most meaningful way to differentiate your company from your competitors, the best way to put distance between you and the crowd is to do an outstanding job with information. How you gather, manage and use information will determine whether you win or lose.

Software substitution, whether it's for drivers or waiters or nurses ... it's progressing. ... Technology over time will reduce demand for jobs, particularly at the lower end of skill set. ... 20 years from now, labor demand for lots of skill sets will be substantially lower. I don’t think people have that in their mental model.

I really do think cancer will largely be a solved problem. I think most of the infectious diseases like malaria - our foundation is very involved - once we're finishing polio eradication, then starting up this malaria eradication, and getting that done as fast as we can.

Life's not fair, get over it!

I'm sorry that we have to have a Washington presence. We thrived during our first 16 years without any of this. I never made a political visit to Washington and we had no people here. It wasn't on our radar screen. We were just making great software.