You have the refugee crisis triggered by Syria. That's got a lot of costs associated with it. Domestically, budgets are incredibly tight because the economy's not generating the growth that makes for easy trade-offs.

In 1990, one in 10 children died before the age of five. That's now down to one in 20, and vaccines were the single biggest factor in that. Had it stayed at 10 percent, 122 million more children would have died.

I think given all the different imperatives - getting energy to Africa, security of energy, climate change, that we should be spending half as much as we spend on health, which will get you all the way up to $15 billion - the health people don't like it when things get compared to their number.

If we can find approaches that meet the needs of the poor in ways that generate profits for business and votes for politicians, we will have found a sustainable way to reduce inequity in the world. This task is open-ended. It can never be finished. But a conscious effort to answer this challenge will change the world.

Learn from your unhappy customers.

This is something we're very committed to, it's something that I think people are underestimating right now as they've seen some of the dot-com promises not come through. I think they're missing the fact that the basic technology is moving forward, the new platforms are here and this vision of the digital decade will be a reality.

It is hard to smash a computer when you're laughing.