(Talking about his first computer) Like all kids we not only fooled around with our toys, we changed them. If you've ever watched a child with a cardboard carton and a box of crayons create a spaceship with cool control panels, or listened to their improvised rules, such as "Red cars can jump all others," then you know that this impulse to make a toy do more is at the heart of innovative childhood play. It is also the essence of creativity.

I believe that every life is valuable. That we can make things better. That innovation is the key to a bright future. That we're just getting started.

For Africa to move forward, you've really got to get rid of malaria.

I don't have any TVs with their over-the-air receivers connected in my house. But when I'm in a hotel room or other places that have a TV, then I turn it on and flip the channels just like everybody else. I'm not immune to the lures of television. I just try to stay away from it because I like to read.

I think when smallpox was eliminated, the whole world got pretty excited about that because it’s just such a dramatic success.

Nigeria has moved into low-middle-income, but their north is very poor, and the health care systems there have broken down.

Online education is pretty special for two reasons. One is that you can get the very best lecture in the world and wherever you are, whenever you want, you can connect to that lecture. The other is this interactivity, where if you know a topic, you can kind of skip over it. Or if you're confused about it, [the area] where you're confused can be analyzed by software.