One of the major problems with long-term deep space human flight is the requirement for radiation shielding.
Buzz AldrinThe feeling of reduced gravity and the limitations of the space suit resulted in a slow-motion movement. Perhaps not too far from a trampoline, but without the springiness and instability.
Buzz AldrinI was the first Navy, Marine or Air Force person who had been an astronaut to return back to the Air Force. I had certain expectations about what would be a reasonable and desirable position to be assigned to after my years of service.
Buzz Aldrin