The reason that viruses are so hard to fight, the reason for example we need a flu virus every year is that they evolve very fast.
Carl ZimmerOver millions of years the viruses in our genome mutate more and more so the look less and less and less recognizable as viruses and so if there was a virus that infected our pre mammal ancestors like 250 million years ago, which it probably did, we can't see it because it just looks totally random.
Carl ZimmerResearchers keep identifying new species, but they have no idea about the life cycle of a given species or its other hosts. They cut open an animal and find a new species. Where did it come from? What effect does it have on its host? What is its next host? They don't know and they don't have time to find out, because there are too many other species waiting to be discovered and described.
Carl Zimmer