I can go back to my very first movie, Thirteen, and think about that exact moment when I saw Nikki Reed and Evan Rachel Wood do their chemistry read audition together. It just came alive. I was filming it with a video camera and I was like, "I know I can make a good movie now."

I was told 50 percent of the population gets cancer. Everybody is going to be affected.

I can go back to my very first movie, Thirteen, and think about that exact moment when I saw Nikki Reed and Evan Rachel Wood do their chemistry read audition together. It just came alive. I was filming it with a video camera and I was like, "I know I can make a good movie now."

The truth is, most of those female stories that are contending for Oscars are directed by men. Let's be honest. I looked at the 44 Oscar contenders in Variety that someone wrote up - there was not one directed by a woman. All the ones that were getting an Oscar pitch with the money and everything behind them were by men.

Since I was a little kid, I did like fairy tale. I did dress up like Little Red Riding Hood. My mom had to make me a cape.

If a scene doesn't work on three levels - it's not advancing the story, the characters, and telling me something new - then put it in the trash.

I thought it would be quite a challenge to direct a mystery thriller. I hadn't really done something like that.