We have to gamble, and sometimes lose as George Ainslie argues; this keeps the appetite for life sharp.

About 70% of what I've written about is centered on the clashes and conformities between the emerging life and physical sciences and older metaphysical frameworks in the 17th and 18th centuries. The other 30% consists of one-off essays or researches into other intriguing contemporary topics such as visual experience, aesthetics, social justice issues, and the epistemology of moral knowledge.

Moral theory develops from the divine command theory of medieval Christian philosophy, mixed up with a bit of ancient pagan virtue theory, to the purely secular moral sentiment and interpersonal reaction theories of Smith and Hume, to Kant's attempt to restore command theory but with something supersensible in the individual rather than God as the source of authority.

Order can arise from chaos without anyone or anything directing the process when unstable combinations of atoms perish and others persist. In the 17th century, Descartes applied this insight to cosmology, and long before Darwin presented his more rigorous ideas about variation and selection, people began to speculate more openly about the origins of life and the species in Epicurean terms.

Highly unequal societies are morally defective because they get to be that way through the exploitation by the clever and well-positioned ones of the vulnerabilities and weaknesses of others. The well-off then use their acquired political power to refuse to make sacrifices for others. This system brings us a wonderful range of products and experiences for consumers at the top of the privilege scale, but it also degrades and benumbs the workers at the lower end, as Adam Smith and Marx both said.

We are now returning to the 18th century empirical approach with the new interest in the evolutionary basis of ethics, with 'experimental' moral philosophy and moral psychology. As a result, we understand better why moral formulas are experienced as ineluctable commands, even if there is no commander and even if the notion of an inescapable obligation is just superstition. So moral philosophy has made huge progress.

Epicurus thought that friendship and conviviality, which require present attention rather than being in an alcoholic stupor, as well as trying to understand and explain things, were the greatest sources of satisfaction in life, so there go most drugs.