Law is par excellence the thing that wants a reason. Now the only possible way of accounting for the laws of nature, and for uniformity in general, is to suppose them results of evolution.

It is certain that the only hope of retroductive reasoning ever reaching the truth is that there may be some natural tendency toward an agreement between the ideas which suggest themselves to the human mind and those which are concerned in the laws of nature.

There is not a single truth of science upon which we ought to bet more than about a million of millions to one.

The pragmatist knows that doubt is an art which hs to be acquired with difficulty.

Kepler's discovery would not have been possible without the doctrine of conics. Now contemporaries of Kepler-such penetrating minds as Descartes and Pascal-were abandoning the study of geometry ... because they said it was so UTTERLY USELESS. There was the future of the human race almost trembling in the balance; for had not the geometry of conic sections already been worked out in large measure, and had their opinion that only sciences apparently useful ought to be pursued, the nineteenth century would have had none of those characters which distinguish it from the ancien régime.

If man were immortal he could be perfectly sure of seeing the day when everything in which he had trusted should betray his trust, and, in short, of coming eventually to hopeless misery. He would break down, at last, as every good fortune, as every dynasty, as every civilization does. In place of this we have death.

We shall do better to abandon the whole attempt to learn the truthunless we can trust to the human mind's having such a powerof guessing right that before very many hypotheses shall have been tried, intelligent guessing may be expected to lead us to one which will support all tests, leaving the vast majority of possible hypotheses unexamined.