People are so involved with immediate care, but at the same time there needs to be investment in educating people as adolescents when they're still HIV negative.

I'm very attracted to characters who don't necessarily make it easy to be loved.

So how critics will perceive your film or your work, or whether your movie is going to make $100 million at the box office, or whether you are going to be winning any awards - well, you have no control over that.

Fran McDormand was great because she said, 'What I used to do when I worked with him was I would just walk on the set and I would give him a big hug. Somehow his guard would just drop.' So I took that advice.

I think there is a part of me that's always a little bit like, "Why would I torture myself? Just in case you forgot how big the shoes are you're walking in, take a look again"

It's ironic that we've built the beauty world around 20-year-olds, when they have no f - kin' concept about wisdom, what life is about, having a few relationships below [their] belt and feeling hardships, to grow into [their] skin and feel confident within [themselves] and to feel the value of who [they] are, not because of a man or because of something like that. And I think that's such a beautiful thing.

Our mechanics are engineered so that we can survive quite a lot, but I think our need to be loved is so great that it’s the thing that damages us the most.