Is it in the UK's interests to leave the EU? It depends on your values. The answer can't be read off of GDP statistics under various scenarios or some measures of global influence.

Ethics is prescriptive and can change behavior, but usually only at the margins.

The most fundamental challenge of the anthropocene concerns agency. For those who lived the Enlightenment dream (always a minority but an influential one), agency was taken for granted. There were existential threats to agency (e.g., determinism) but philosophy mobilized to refute these threats (e.g., by defending libertarianism) or to defuse them (e.g., by showing that they were compatible with agency).

If I drive my car to the store, those carbon molecules that are emitted actually get into the atmosphere circulation systems and affect climate in a global basis. This is shocking, this is amazing! No one in the 18th Century would have believed that anything like this were at all possible and I don't think we have, as part of our common sense, morality, norms and values that are really responsive to those kinds of issues, to the kind of power that we now are able to exert over the future and over people who live very far from us.

People with long memories and a vivid sense of the past have an immediate understanding of politicians like Donald Trump. They are not surprised by the behavior of Google, a corporation that notionally (until recently anyway) espoused the slogan "don't be evil" and then runs over individual people and even entire nations in the pursuit of profit.

Increasingly both environmentalists and animal ethicists recognize the enormous destruction caused by animal agriculture.

It is probably true that the economic benefits of being in the EU are a net positive to the UK, but a large number of people do not share in these benefits and the result is increasing inequality.