You try to make the world a better place and what does it get you? I mean, Christ, how the hell does one man stand a chance against four billion assholes?

I lose faith in everything else, but rarely in my work. If I start to get bored, I change it to make it more interesting. I try not to take it too seriously, but I also try to never cheat or hurry things along.

I originally just wanted to be an artist.

The greatest moment of my life was, somebody sent me a cable-access show from Chicago that had Joey Ramone on it showing the video we made together. And he was talking about, like, "This guy Dan Clowes postponed his wedding for us. He's a great guy."

Avatar is a total nerd thing, and yet our popular culture has somehow made all that stuff acceptable.

Comics seldom move me the way I would be moved by a novel or movie.

It's much more liberating as a artist to feel like you can approach each page and each panel with the way that inspires you the most. I think the thing that bogs down a lot of artists is that you're kind of stuck drawing in a style you've developed.