There may be things that are completely unknowable to us, so we must be careful not to treat the limits of our knowledge as sure guides to the limit of what there is.

Try to acquire the weird practice of savoring your mistakes, delighting in uncovering the strange quirks that led you astray. Then, when you have sucked out all the goodness to be gained from having made them, you can cheerfully forget them and go on to the next big opportunity.

The chief trick to making good mistakes is not to hide them - especially not from yourself. Instead of turning away in denial when you make a mistake, you should become a connoisseur of your own mistakes, turning them over in your mind as if they were works of art, which in a way they are.

If I were to give a prize for the single best idea anybody ever had, I'd give it to Darwin for the idea of natural selection - ahead of Newton, ahead of Einstein - because his idea unites the two most disparate features of our universe: the world of purposeless, meaningless matter and motion, particles jostling on the one side, and the world of meaning and purpose, design on the other.

If you can approach the world's complexities, both its glories and its horrors, with an attitude of humble curiosity, acknowledging that however deeply you have seen, you have only scratched the surface, you will find worlds within worlds, beauties you could not heretofore imagine, and your own mundane preoccupations will shrink to proper size, not all that important in the greater scheme of things.

Isn't it true that whatever isn't determined by our genes must be determined by our environment? What else is there? There's Nature and there's Nurture. Is there also some X, some further contributor to what we are? There's Chance. Luck. This extra ingredient is important but doesn't have to come from the quantum bowels of our atoms or from some distant star. It is all around us in the causeless coin-flipping of our noisy world, automatically filling in the gaps of specification left unfixed by our genes, and unfixed by salient causes in our environment.

There is a time for politeness and there is a time when you are obliged to be rude.