In 50 years - or 20 years, or 200 years - our current epistemic horizon (the Big Bang, roughly) may look as parochial as the horizon Newton had to settle for in his day, but no doubt there will still be good questions whose answers elude us.

The haven all memes depend on reaching is the human mind, but a human mind is itself an artifact created when memes restructure a human brain in order to make it a better habitat for memes.

I think that what one can see from a Darwinian account is how the addition of culture in our species turns us into a very special sort of animal, an animal that can be a moral agent in a way that no other animal can be.

If the concept of consciousness were to fall to science, what would happen to our sense of moral agency and free will? If conscious experience were reduced somehow to mere matter in motion, what would happen to our appreciation of love and pain and dreams and joy? If conscious human beings were just animated material objects, how could anything we do to them be right or wrong?

We live in a world that is subjectively open. And we are designed by evolution to be "informavores", epistemically hungry seekers of information, in an endless quest to improve our purchase on the world, the better to make decisions about our subjectively open future.

...but I also can't prove that mushrooms could not be intergalactic spaceships spying on us.

Cults and prophets proclaiming the imminent end of the world have been with us for several millennia, and it has been another sour sort of fun to ridicule them the morning after, when they discover that their calculations were a little off. But, just as with Marxists, there are some among them who are working hard to "hasten the inevitable," not merely anticipating the End Days with joy in their hearts, but taking political action to bring about the conditions they think are the prerequisites for that occasion.