It’s probably the most unpopular policy I’m responsible for. I know it is very unpopular, culling badgers. But I believe it is the right thing to do. You have to make choices as a politician. Sometimes it means doing something you know people don’t like.

Countries are different. They make different choices. We cannot harmonise everything. For example, it is neither right nor necessary to claim that the integrity of the single market, or full membership of the European Union requires the working hours of British hospital doctors to be set in Brussels irrespective of the views of British parliamentarians and practitioners.

My question right now would be to Colonel Gaddafi, which is: 'What on earth do you think you are doing? Stop it.'

We're all agreed that climate change is one of the greatest and most daunting challenges of our age. We have a moral imperative to act and act now.

More of the same will just produce more of the same - less competitiveness, less growth, fewer jobs.

The legacy of Mandela is to have brought the country together... South Africa can be one of the success stories of the 21st century.

We are a great country, and whatever choice we make we will still be great. But I believe the choice is between being an even greater Britain inside a reformed EU or a great leap into the unknown.