[Chuck's wife] was standing behind me at the time and she said, 'Chuck hasn't fed himself in 19 years. So, you've got a choice: We keep the arm, or you keep Chuck.'

Education, actual learning - it is hard work. It's very personal. Your parents don't teach you anything. Your teachers don't teach you anything. The government doesn't teach you anything. You read it. You don't understand it; you read it again. You break a pencil and read it again.

The word entrepreneur is associated with success and adventure. From my life, the only thing I can tell you that's consistently associated with entrepreneurship is failure, and the only thing consistently associated with invention is frustration. There is a long road between the idea and the reality.

If history is any indication, all truths will eventually turn out to be false.

I think in our lifetime, that level of acceptance of "well, we couldn't do any better," won't be tolerated. We're going to start to see individual therapies customized for individual patients, and it's going to change the way people get healthcare.

I think we have a society which is spending more and more of its money on healthcare as a percent of GDP as a percent of a lot of things. I think that's a measure of success.

It’s not what you do – it’s what you are becoming.