A great advantage of X-ray analysis as a method of chemical structure analysis is its power to show some totally unexpected and surprising structure with, at the same time, complete certainty.

The detailed geometry of the coenzyme molecule as a whole is fascinating in its complexity.

I used to say the evening that I developed the first x-ray photograph I took of insulin in 1935 was the most exciting moment of my life. But the Saturday afternoon in late July 1969, when we realized that the insulin electron density map was interpretable, runs that moment very close.

A great advantage of X-ray analysis as a method of chemical structure analysis is its power to show some totally unexpected and surprising structure with, at the same time, complete certainty.

I should not like to leave an impression that all structural problems can be settled by X-ray analysis or that all crystal structures are easy to solve. I seem to have spent much more of my life not solving structures than solving them.

I was captured for life by chemistry and by crystals.

Still I had a lurking question. Would it not be better if one could really 'see' whether molecules as complicated as the sterols, or strychnine were just as experiment suggested?