The search for knowledge is in our genes. It was put there by our distant ancestors who spread across the world, and it's never going to be quenched.

These slender little people (Homo Habilis), the size of modern 12 year olds, were devoid of fangs and claws and almost certainly slower on foot than the four legged animals around them. They could have succeeded in their new way of life only by relying on tools and sophisticated cooperative behavior

By any reasonable measure of achievement, the faith of the Enlightenment thinkers in science was justified.

On the lawn next to the sidewalk a fire ant colony is swarming. The ants are pouring out of a mound nest, here no more than an irregular pile of dirt partly flattened by the last pass of a lawnmower. Winged queens and males are taking off on their nuptial flight, protected by angry-looking workers that run up and down the grass blades and out onto the blistering-hot concrete of the sidewalk. The species is unmistakably Solenopsis geminata, the native fire ant.

No barrier stands between the material world of science and the sensibilities of the hunter and the poet.

The second half of the 20th century was a golden age of molecular biology, and it was one of the golden ages of the history of science. Molecular biology was so successful and made such a powerful alliance with the medical scientists that the two together just flourished. And they continue to flourish.

A paradigm shift is the best a scientist can hope for. Whenever I smell an opportunity like that, I go after it. You have a new discovery that something's working in a different way than you thought. And this is particularly true in molecular and cell biology, which is structural biology and has the least potential for controversy and partisanship among the biological scientists. You're dealing with a concrete object that's either there or not there.