A paradigm shift is the best a scientist can hope for. Whenever I smell an opportunity like that, I go after it. You have a new discovery that something's working in a different way than you thought. And this is particularly true in molecular and cell biology, which is structural biology and has the least potential for controversy and partisanship among the biological scientists. You're dealing with a concrete object that's either there or not there.

So in my freshman year at the University of Alabama, learning the literature on evolution, what was known about it biologically, just gradually transformed me by taking me out of literalism and increasingly into a more secular, scientific view of the world.

People respect nonfiction but they read novels.

Humanity needs a vision of an expanding and unending future.

[T]he true natural sciences lock together in theory and evidence to form the ineradicable technical base of modern civilization. The pseudosciences satisfy personal psychological needs... but lack the ideas or the means to contribute to the technical base.

All my life I have placed great store in civility and good manners, practices I find scarce among the often hard-edged, badly socialized scientists with whom I associate. Tone of voice means a great deal to me in the course of debate. I despise the arrogance and doting self-regard so frequently found among the very bright.

Human existence may be simpler than we thought. There is no predestination, no unfathomed mystery of life. Demons and gods do not vie for our allegiance. Instead, we are self-made, independent, alone, and fragile, a biological species adapted to live in a biological world. What counts for long-term survival is intelligent self-understanding, based upon a greater independence of thought than that tolerated today even in our most advanced democratic societies.