You make adjustments according to the specifics of the character.It's something I feel like a lot of my comedic heroes have always done. It's not even necessarily vulnerability, always, but it's an earnestness, a genuine desire to actually do the right thing, but then still make really misguided, stupid decisions along the way.

We did some camera tests blacking it out, we made a prosthetic with a gap in it, but that made me look like a donkey, so I vetoed that right away. And then I just finally called my dentist and said, 'You know, I've had this implant for 20 years. What's it involve in taking it out?' And he said, 'It's actually not that big a deal. We can do that.' So we took it out and I was toothless for three months, for the run of the movie [ The Hangover] .I take my job very seriously.

Working on The Daily Show, I co-produced all those field segments, and that's another huge thing.I probably did more than 100 field segments.

To be totally candid, it was really born out of a panic attack the summer between my sophomore and junior years, when I realized I wasn't going to graduate in four years unless I somehow managed to glue together all the courses I'd taken. That said, I'm really glad I did it, 'cause it was really fun, and I was able to just take whatever the hell I wanted.

I'm pretty sure no one's reading action scripts saying, 'This has got to be Ed Helms.'

There are currently more political parties in Iraq than unbombed buildings to hold them.

I lived in New York for 10 years, I loved it, I never second-guessed it. There were definitely times when I thought, "I will never leave this place." And I kind of got into that center-of-the-universe mindset.