A lot of good ideas are actually bad ideas because, since they sound good, everybody's already doing them.

For the last century of neuroscience, lots of people have tried to control neurons using all sorts of different technologies - pharmacology (drugs), electrical pulses, and so on. But none of these technologies are precise. With optogenetics, we can aim light at a single cell, or a set of cells, and turn just that set of cells on or off.

You can imagine over very long timescales, perhaps far beyond the multi-decade time scale, we might be able to ask very deep questions about why we feel the way we feel about things, or why we think of ourselves in certain ways - questions that have been in the realm of psychology and philosophy but have been very difficult to get a firm mechanistic laws-of-physics grasp on.

Work backward from your goal.

If our brain is understanding some parts of the universe and not understanding other parts, and those understandings are about the laws of physics that our brains are built on top of, then it's kind of a loop, right?

A big part of my job is to remember failure, and reboot failure, when the timing is right.

It's actually kind of weird that we can comprehend the law of gravity, or that we can understand quantum mechanics, enough at least to make computers.