Earlier this week ... scientists announced the completion of a task that once seemed unimaginable; and that is, the deciphering of the entire DNA sequence of the human genetic code. This amazing accomplishment is likely to affect the 21st century as profoundly as the invention of the computer or the splitting of the atom affected the 20th century. I believe that the 21st century will be the century of life sciences, and nothing makes that point more clearly than this momentous discovery. It will revolutionize medicine as we know it today.

The stark and tragic images of human suffering in the aftermath of Hurricane Katrina have reminded us yet again that civil rights and equal rights are still the great unfinished business of America. The suffering has been disproportionately borne by the weak, the poor, the elderly and infirm, and largely African-Americans, who were forced by poverty, illness, unequal opportunity to stay behind and bear the brunt of the storm's winds and floods. I believe that kind of disparate impact is morally wrong in this, the richest country in the world.

I favor access to discrimination on the basis of sexual orientation.

Do we operate under a system of equal justice under law? Or is there one system for the average citizen and another for the high and mighty?

My father lifted me up in his strong gentle arms and said something I will never forget. He said, "I know you can do it. There is nothing that you can't do. We're going to climb that hill together even if it takes us all day." And at age 12 losing your leg pretty much seems like the end of the world. But as I climbed onto his back and we flew down the hill that day, I knew he was right. I knew I was going to be OK. You see, my father taught me that even our most profound losses are survivable. And it is what we do with that loss - our ability to transform it into a positive event.

I don't think you're going to be a success in anything if you think about losing, whether it's in sports or in politics.

Historians will come to their own judgments about President Kennedy. Here is how I choose to remember him. He was an heir to wealth who felt the anguish of the poor. He was an orator of excellence who spoke for the voiceless. He was a son of Harvard who reached out to the sons and daughters of Appalachia. He was a man of special grace who had a special care for the retarded and handicapped. He was a hero of war who fought hardest for peace. He said and proved in word and deed that one man can make a difference.