In an era when too many Americans are losing their jobs or working for less, trying to make ends meet, in close cases Judge [Samuel] Alito has ruled the vast majority of the time against the claims of the individual citizens. He has acted instead in favor of government, large corporations and other powerful interests.

Even one justice can advance or reverse the progress of our journey.

If we set the precedent of limiting the First Amendment, in order to protect the sensibilities of those who are offended by flag burning, what will we say the next time someone is offended by some other minority view, or by some other person's exercise of the freedom the Constitution is supposed to protect?

Earlier this week ... scientists announced the completion of a task that once seemed unimaginable; and that is, the deciphering of the entire DNA sequence of the human genetic code. This amazing accomplishment is likely to affect the 21st century as profoundly as the invention of the computer or the splitting of the atom affected the 20th century. I believe that the 21st century will be the century of life sciences, and nothing makes that point more clearly than this momentous discovery. It will revolutionize medicine as we know it today.

When I look at that record in light of the 1985 job application to the [Ronald] Reagan Justice Department, it's even more troubling.That document lays out an ideological agenda that highlights Judge Samuel Alito in belonging to an alumni group at Princeton that opposed the admission of women and proposed to curb the admission of racial minorities.

Integrity is the lifeblood of democracy. Deceit is a poison in its veins.

Violence is an admission that one's ideas and goals cannot prevail on their own merits.