Focus on something that has high value to someone else, be really rigorous in making that assessment, because natural human tendency is wishful thinking, so the challenge to entrepreneurs is telling what's the difference between really believing in your ideals and sticking to them as opposed to pursuing some unrealistic dream that doesn't actually have merit, be very rigorous in your self analysis, certainly being extremely tenacious, and just work like hell. Put in 80-100 hours every week. All these things improves the odds of success

One bit of advice: it is important to view knowledge as sort of a semantic tree - make sure you understand the fundamental principles, ie the trunk and big branches, before you get into the leaves/details or there is nothing for them to hang on to.

People work better when they know what the goal is and why. It is important that people look forward to coming to work in the morning and enjoy working.

We need to be super careful with AI. Potentially more dangerous than nukes.

The idea of lying on a beach as my main thing just sounds like the worst. It sounds horrible to me. I would go bonkers. I would have to be on serious drugs. I'd be super-duper bored. I like high intensity.

It is definitely true that the fundamental enabling technology for electric cars is lithium-ion as a cell chemistry technology. In the absence of that, I don't think it's possible to make an electric car that is competitive with a gasoline car.

Physics is a good framework for thinking. ... Boil things down to their fundamental truths and reason up from there.