When something is important enough, you do it even if the odds are not in your favor.

Many things are improbable, only a few are impossible.

We need to be super careful with AI. Potentially more dangerous than nukes.

It's obviously tricky to convert cellulose to a useful biofuel. I think actually the most efficient way to use cellulose is to burn it in a co-generation power plant. That will yield the most energy and that is something you can do today.

Focus on something that has high value to someone else, be really rigorous in making that assessment, because natural human tendency is wishful thinking, so the challenge to entrepreneurs is telling what's the difference between really believing in your ideals and sticking to them as opposed to pursuing some unrealistic dream that doesn't actually have merit, be very rigorous in your self analysis, certainly being extremely tenacious, and just work like hell. Put in 80-100 hours every week. All these things improves the odds of success

If something's important enough, you should try. Even if you - the probable outcome is failure.

I think you should always be seeking negative feedback.