The first step is to establish that something is possible; then probability will occur.

Facebook is quite entrenched and has a network effect. It's hard to break into a network once it's formed.

Work like hell. I mean you just have to put in 80 to 100 hour weeks every week. [This] improves the odds of success. If other people are putting in 40 hour work weeks and you’re putting in 100 hour work weeks, then even if you’re doing the same thing you know that you will achieve in 4 months what it takes them a year to achieve.

Talent is extremely important. It's like a sports team, the team that has the best individual player will often win, but then there’s a multiplier from how those players work together and the strategy they employ.

If anyone thinks they'd rather be in a different part of history, they're probably not a very good student of history. Life sucked in the old days. People knew very little, and you were likely to die at a young age of some horrible disease. You'd probably have no teeth by now. It would be particularly awful if you were a woman.

With artificial intelligence we are summoning the demon.

The United States is definitely ahead in culture of innovation. If someone wants to accomplish great things, there is no better place than the U.S.