When I read the script for Will & Grace in 1998, I knew I was the only guy for the part.

I think because the show ["Grant MacLaren"] is essentially a hopeful show. The show says that as bleak as the future is, the one thing that mankind developed was the ability to send their consciousness back and where a lot of the institutions of modern life have fallen apart.

Back then, all the networks were still making a movie a week, virtually. So I did five of them that year. So it was just a nonstop... '92 was a great, nonstop ride in Vancouver.

I was playing this sort of asshole actor [in The Jenny McCarthy Show]. And we shot the pilot, and it was a guaranteed go. It was going to be 24 [episodes] on the air. No questions from NBC. And we shot the pilot, and I was in Toronto doing a movie, and I got a call saying they cut the character, that I was off the show.

I grew up on M*A*S*H and All In The Family and Cheers. And then around this time, this would have been '95, '96, I was so into Friends and Mad About You, the idea of being on a sitcom became a very real thing that I wanted. It was not so much a relief. It was really exciting. It's an amazing thing to be in front of an audience.

The Andromeda strain is a killer disease that they've got to prevent from spreading to being 100 percent contagious. It's another one where we're racing to save humanity.

That was my big break [Lonesome Dove]. My first real kind of adult role on something really well-written. It was a spin-off of the miniseries, and I played Col. Mosby, a very dangerous, Southern colonel in post-Civil War, wandering the West.