When I read the script for Will & Grace in 1998, I knew I was the only guy for the part.

I think there's a certain objectivity that comes from being Canadian. You're partly British and partly American; you have a good bird's-eye view of both countries. So much of the comedy that comes out of Canada is impersonation - it's less 'look at me' than it is 'look at me playing other people.

Most people, if you live in a big city, you see some form of schizophrenia every day, and it’s always in the form of someone homeless. “Look at that guy - he’s crazy. He looks dangerous.” Well, he’s on the streets because of mental illness. He probably had a job and a home...

Every actor has periods of their life that are a little less busy than others, and that was just a time when I needed that. And to be back on a sitcom stage, with Julia [ Louis-Dreyfus], was really, really fun.

The Andromeda strain is a killer disease that they've got to prevent from spreading to being 100 percent contagious. It's another one where we're racing to save humanity.

I love playing anyone that does stuff that I don't do. The fun of playing an assassin is that I've never killed anybody. The fun of playing a brilliant musician is that I don't actually play any instruments.

Growing up, my father was a financial analyst for an oil company. He was just a regular dad. And when I would say, Hey, come see my play, hed say, Sure. Hed see one, Oh, good play - you know, very typical dad reaction.