Most people, if you live in a big city, you see some form of schizophrenia every day, and it’s always in the form of someone homeless. “Look at that guy - he’s crazy. He looks dangerous.” Well, he’s on the streets because of mental illness. He probably had a job and a home...

They're such different things [Townies and Lonesome Dove]. I certainly love them both. Certainly Lonesome Dove would be way hard now, because, I mean, back then I wasn't married.

I have accomplished a lot, but it didn't happen overnight for me. I was 35 when I got the show, and had been working professionally for 15 years. It would be a lot weirder if I were in my early 20s and stumbled into it.

We didn't, with 'Will & Grace,' set out to change the gay world. We just set out to be funny.

When I read the script for Will & Grace in 1998, I knew I was the only guy for the part.

You make a lot of mistakes. I haven't seen that movie [The Lost World] in 20 years. But if I saw it, I'm sure I could pick out a whole lot of mistakes.

I'd done a pilot [of Townies] with Caroline Rhea [Pride & Joy] that didn't go anywhere.