It is widely grokked that cats have the hacker nature

Lisp is worth learning for the profound enlightenment experience you will have when you finally get it; that experience will make you a better programmer for the rest of your days, even if you never actually use Lisp itself a lot.

Rushing to optimize before the bottlenecks are known may be the only error to have ruined more designs than feature creep. From tortured code to incomprehensible data layouts, the results of obsessing about speed or memory or disk usage at the expense of transparency and simplicity are everywhere. They spawn innumerable bugs and cost millions of man-hours - often, just to get marginal gains in the use of some resource much less expensive than debugging time

The next best thing to having good ideas is recognizing good ideas from your users. Sometimes the latter is better.

The easiest programs to use are those which demand the least new learning from the user

Smart data structures and dumb code works a lot better than the other way around.

I believe, but cannot prove, that global “AIDS” is a whole cluster of unrelated diseases all of which have been swept under a single rug for essentially political reasons, and that the identification of HIV as the sole pathogen is likely to go down as one of the most colossal blunders in the history of medicine.