The most consequential change in man's view of the world, of living nature and of himself came with the introduction, over a period of some 100 years beginning only in the 18th century, of the idea of change itself, of change over periods of time: in a word, of evolution.

Isolating mechanisms are biological properties of individuals that prevent the interbreeding of populations that are actually or potentially sympatric.

Every politician, clergyman, educator, or physician, in short, anyone dealing with human individuals, is bound to make grave mistakes if he ignores these two great truths of population zoology: (1) no two individuals are alike, and (2) both environment and genetic endowment make a contribution to nearly every trait.

Given the fact of evolution, one would expect the fossils to document a gradual steady change from ancestral forms to the descendants. But this is not what the paleontologist finds. Instead, he or she finds gaps in just about every phyletic series.

The issue, as correctly emphasized by Carl Sagan, is the probability of the evolution of high intelligence and an electronic civilization on an inhabited world. Once we have life (and almost surely it will be very different from life on Earth), what is the probability of its developing a lineage with high intelligence? On Earth, among millions of lineages of organisms and perhaps 50 billion speciation events, only one led to high intelligence; this makes me believe in its utter improbability.

I had found again and again that the most aberrant population of a species - often having reached species rank, and occasionally classified even as a separate genus - occurred at a peripheral location, indeed usually at the most isolated peripheral location.

Living in an entirely different physical as well as biotic environment, such a population would have unique opportunities to enter new niches and to select novel adaptive pathways.