In recent years, we have seen technology advance at lightning speed, allowing us to accomplish lifesaving feats never imagined before. It is our responsibility to ensure that these advances are used for positive medical breakthroughs, and not allowed to restrict rights or limit access to health insurance or job opportunities.

Challenges of historic import threaten America's future. Action on the deficit, economy, energy, health care and much more is imperative, yet our legislative institutions fail to act. Congress must be reformed.

Across the country military families are facing dire financial circumstances due to longer than expected tours of duties. They are being penalized for their patriotism - no one should have to choose between doing right by their country and doing right by their families.

You now have six-year campaigns for the Senate - you never stop running. It's not uncommon for a member of the Senate to have a fundraising breakfast, a fundraising lunch and a fundraising dinner, and then when the Senate breaks for the week to go home, more fundraisers. And that's driven by the cost of campaigning.

We must do all we can to help improve the deplorable human rights situation of the North Korean people.

Filibusters have proliferated because under current rules just one or two determined senators can stop the Senate from functioning. Today, the mere threat of a filibuster is enough to stop a vote; senators are rarely asked to pull all-nighters like Jimmy Stewart in 'Mr. Smith Goes to Washington.'

People come into public life for different reasons. None of us are ego-challenged, I think, or we probably wouldn't be doing what we're doing, so if anyone tells you that they don't like the sound of the applause and the ego gratification, I don't think they're being straight with you.