[Decoding the human genome sequence] is the most significant undertaking that we have mounted so far in an organized way in all of science. I believe that reading our blueprints, cataloguing our own instruction book, will be judged by history as more significant than even splitting the atom or going to the moon.

We give our kids vaccinations. That's a biological enhancement that's considered not just acceptable but actually admirable.

To get our universe, with all of its potential for complexities or any kind of potential for any kind of life-form, everything has to be precisely defined on this knife edge of improbability. [Y]ou have to see the hands of a creator who set the parameters to be just so because the creator was interested in something a little more complicated than random particles.

It's not like you're closing the old doors and that investigators working away in a laboratories on a unique hypothesis are no longer needed. My gosh, they are indeed. But this becomes a real engine for hypothesis generation and even for proof if you have interventions that you can carry out in this kind of large scale and conduct them in a rigorous way. I guess, yeah, it's different. But it's different in a good way.

Research is so unpredictable. There are periods when nothing works and all your experiments are a disaster and all your hypotheses are wrong.

Scientists must venture outside their comfort zones to show the public how cool - and how important - their work really is.

A lot of people think PMI is the genome project 2.0. No. This is about all the influences on disease - genetics is in there, but the environment is in there as well, health choices, behaviors, all the factors that are important, otherwise we're not doing what we promised we would do - which is in a holistic way look at how people stay healthy or how do they fall ill.