When you make a breakthrough it is a moment of scientific exhilaration because you have been on this search and seem to have found it. But it is also a moment where I at least feel closeness to the creator in the sense of having now perceived something that no human knew before but God knew all along.
Francis CollinsWhen a drug comes out [that's broadly prescribed] there are going to start to be a lot of people on it [in a million person cohort] and you might get therefore an early signal of something unexpected that hadn't come through in the clinical trials. And I'm sure [drug companies] would love it if, in fact, FDA, recognizing that, would say, OK, maybe you don't have to do your trial with 30,000 people because we're going to find out shortly after registration because we'll have a lot of people taking the drug and we'll be able to see what happened using PMI.
Francis CollinsIt's not like you're closing the old doors and that investigators working away in a laboratories on a unique hypothesis are no longer needed. My gosh, they are indeed. But this becomes a real engine for hypothesis generation and even for proof if you have interventions that you can carry out in this kind of large scale and conduct them in a rigorous way. I guess, yeah, it's different. But it's different in a good way.
Francis Collins