It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule.
Francis CrickTrying to determine the structure of a protein by UV spectroscopy was like trying to determine the structure of a piano by listening to the sound it made while being dropped down a flight of stairs.
Francis CrickIt has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.
Francis CrickA final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.
Francis Crick